Preformulation Services

LATITUDE’s preformulation services provide key information for formulating APIs in solutions or solids.

Our solution phase program evaluates:

  • pH solubility profile and buffer compatibility
  • Solubility in pharmaceutically useful solvents
  • Drug solubilizer screening
  • Ionization constants
  • Partition coefficients
  • Drug-excipient compatibility, screening

Our solid state program evaluates:

  • Salt form selection
  • Morphology study
  • Hygroscopicity evaluation
  • Thermal characterization
  • Particle size and size distribution
  • Powder density, flowability and compressibility
  • Drug-excipient compatibility

LATITUDE’s efficient and unique approaches use a minimum quantity of drug substance to complete a preformulation evaluation. A comprehensive preformulation evaluation, including analytical HPLC method development, typically requires as little as 1-2 grams of API.